Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

THIS IS DEFINITELY A STEM CELL THERAPY SUCCESS STORY.  CORD BLOOD STEM CELLS ARE THE HEROES THIS TIME.  THE STEM CELLS USED IN THIS STEM CELL TRANSPLANT WERE HIS SISTER'S CORD BLOOD STEM CELLS.   HOPEFULLY, DIKSHIT GOWDA WILL MAKE A FULL RECOVERY...THUS INCREASING THE LEAD OF VICTORIES FOR ADULT STEM CELLS  (MULTIPLE THOUSANDS) OVER VICTORIES FOR  EMBRYONIC STEM CELLS (ZERO)

Kolkata, Mar 6: A four year-old boy suffering from thalassaemia has recovered after being injected with his sister's cord blood. The new development has raised hopes for the treatment mode using stem-cell transplant.

Thalassaemia is an inherited blood disorder.

Due to the disease, the white blood cell count of Dikshit Gowda, hailing from Bangalore, has dropped to zero. He was admitted to the Netaji Subhas Chandra Bose Cancer Research Institute here on February 7.

"Initially, the bone marrow of Gowda was destroyed when he was treated for 15 days using high dose of chemotherapy," its Director Ashis Mukherjee said.

"Thereafter, stem cells taken from his little sister's cord blood, preserved at the Cryo Stem Cell Institute in Bangalore, were injected into him on February 28," he said.

"He is doing well now though he will be kept under observation for at least a month," Mukherjee said.

"This is the first stem-cell transplant in eastern India and it will be first of its kind in the country using mismatch cord blood," he said.

The boy's white blood cell count was now rising and he could be released in six weeks "if everything goes well. It gives us hope that the treatment mode was successful."

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

THIS ARTICLE IS GREAT NEWS INDEED. IT SEEMS ADULT STEM CELLS ARE BEING USED NOW TO HELP REPAIR BONES, LIGAMENTS, CARTILAGE, SPINAL CORD AND NERVES. THIS WONDERFUL STORY GIVES HOPE TO PATIENTS WHO MAY NEED A HIP REPLACEMENT OR KNEE REPLACEMENT. PERHAPS OUR CANADIAN READERS (due to their healthcare system) WON'T HAVE TO WAIT 2 YEARS FOR A HIP REPLACEMENT ANYMORE AND WILL BE ABLE TO SIMPLY USE THEIR OWN STEM CELLS TO HELP THEM :).

By Debra Sherman

SAN FRANCISCO (Reuters) - The orthopedics industry is using more biology and less metal to repair injured and diseased joints.

Researchers attending the annual meeting of the American Academy of Orthopaedic Surgeons in San Francisco this week said they are slowly unlocking the doors to regenerative medicine using stem cells, gene therapy and tissue engineering.

"It's the future of our specialty," said Dr. Thomas Einhorn, chairman of the Department of Orthopedic Surgery and professor of orthopedic surgery, biochemistry and biomedical engineering at Boston University.

Historically, the orthopedist's arsenal looked much like a carpenter's. It was dominated by heavy metal -- cages, screws, saws, drills and metal implants for joints such as hips and knees.

Stem cell therapy could eventually eliminate the need for joint replacement, said Einhorn, who last year performed his first hip replacement surgery using the patient's own stem cells.

The undifferentiated, unspecialized stem cells can morph into specialized cells with specific functions in the body. Adult stem cells are available from a number of sources, including bone marrow and fat.

Stem cells from a patient's own body are being used to repair bones, ligaments, cartilage, muscle, spinal cord and nerves.

In the hip replacement surgery, Einhorn extracted bone marrow from a middle-aged male patient, sent it to a lab that removed everything but the stem cells, then put the cells in a spray gun and coated the hip implant to induce rapid bone growth over the implant.

"I don't know if I'll see it in my career, but we're certainly moving that way. It might take 20 years before we can totally regenerate a joint that way," Einhorn said.

Dr. Scott Rodeo, co-chief of Sports Medicine and Shoulder Service at the Hospital for Special Surgery in New York and an associate team physician for the Super Bowl champion New York Giants, said animal studies suggest that stem cells and bone morphogenic proteins (BMPs) can be used to repair rotator cuff tears in the shoulder, a common sports injury that often requires surgery.

BMPs are a group of growth factors and cytokines known for their ability to induce the formation of bone and cartilage. They are sold by Medtronic Inc and Stryker Corp.

Stem cell therapy may also have applications in spine fusion, said Dr. Scott Boden of Emory Spine Center.

"We have a tougher time in the spine," he said, adding that it may just require more cells to form bone there.

Implanting BMPs may "attract other stem cells to the site and tell them to become bone cells," he said.

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

AS REGULAR READERS KNOW, I CONSIDER AMERICA “THE BANGLADESH OF STEM CELLS.  LIKE CHILDREN LOST IN A FOREST, AMERICA WANDERS AROUND, HOPELESSLY CAUGHT UP IN A POLITICAL/RELIGIOUS BATTLE OVER THE SCIENCE FICTION OF EMBRYONIC STEM CELLS. AS FAR AS THE REAL SCIENCE OF ADULT STEM CELLS IS CONCERNED, CHINA AND INDIA ARE SO FAR AHEAD OF THE USA THAT AMERICA MAY NEVER CATCH UP. 

 

HERE IS A FEB.2008 ARTICLE FROM INDIA.  IT IS SAFE TO SAY THAT WHILE A PRECIOUS FEW AMERICAN RESEARCHERS KNOW SOME OF THE FACTS IN THIS ARTICLE, NONE OF THEM WILL BE INVOLVED IN THIS CUTTING EDGE RESEARCH DURING THIS DECADE, IF EVER, IN THE LAND OF THE FREE.  FURTHER, IN MY OPINION, EMBRYONIC STEM CELLS WILL NOT BE IMPLANTED INTO HUMANS TO HELP CURE THE BELOW DISEASES DURING THE LIFETIMES OF AMERICANS SUFFERING FROM THESE DISEASES TODAY.---DM

 

EXTRACTED FROM THE DECCAN HERALD, FEB 5, 2008.

 

http://www.deccanherald.com/Content/Feb52008/snt2008020550496.asp

 

Stempeutics has been doing some pioneering work on stem cells with a focus on "benchside to bedside", as the manager, Manohar says. "We do not want to be doing research that is too basic to be applied."

At present, four major clinical trials with 100 patients each are ongoing in cerebral strokes (!), limb Ischemia (!), myocardial infarction and multiple sclerosis (!).  (OF THESE FOUR, ONLY MYOCARDIAL INFARCTION IS CURRENTLTLY IN CLINICAL TRIAL IN THE USA---DM)  These are some diseases for which pilot tests have shown satisfactory to good results. Parkinson's is another ailment that has responded well but as it involves brain surgery, is a bit more complicated.

Calling it experimental therapy, Manohar says that almost 80 patients have been treated using mesenchymal stem cells, found in the bone marrow. "In the last six months alone almost 40 patients have been treated and in 25 per cent of the cases, the results were good. While the Parkinson's patients showed remarkable recovery (TAKE NOTE, MICHAEL J. FOX. AS CHRISTOPHER REEVE DID, YOU ARE WASTING YOUR LIFE CHAMPIONING EMBRYONIC SCIENCE FICTION WHICH EXISTS ONLY BY PRETENDING THAT WHAT CAN HELP YOU NOW---ASC-- DOES NOT WORKDM)  with many even stopping the drug, with spinal cord injuries there was mixed results," says Dr Totey. It was found that the cells were not migrating to the site.

One of the reasons he cited could be the mode of delivery of stem cells. Usually it is delivered at the site of injury, or through lumbar puncture or the arterial route. The site of injury is the best approach, though in the case of brain diseases, this means complications.

The stem cell treatment works well for fresh injuries but some experts believe that the body sends stem cells naturally in this period. After six months or so, the scar tissue forms and can hinder the migration of stem cells administered.

A patient from Rajkot had been paralysed after falling from a giant wheel at Essel World. After two years the family contacted Manipal hospital in 2006. "We did the MRI scan and identified the injury points on the spine and at these places we made incisions to take out the scar tissue. It became a fresh injury so the stem cells we injected went unhindered to the damaged spot," notes Dr Totey.

Now she has recovered to a large extent, can move around and has control of the bladder, etc. She required two injections so far, of stem cells drawn from her bone marrow.

Unlike usual bone marrow transplants where a litre of the liquid is drawn each time, with mesenchymal adult stem cells, all that is required is 30-60 ml which can be cultured in the lab for future use as well, he says.
Unlike most other adult stem cells, mesenchymal are pluripotent and can grow into any tissue. The other big advantage is that there is no need for matching. Any donor can donate cells from his bone marrow. As it takes 20-25 days to culture the stem cells in lab, this is an advantage as readily available cells can be administered in emergency situations instead of having to draw from the patient's bone marrow and culture.

"The problem is in isolation and culturing. Very small quantities of the cell are present in the bone marrow. We have patented the technology," says Totey.

In the case of cerebral stroke, the problem arises in delivering stem cells due to the blood brain barrier. This is a natural barrier of the body which prevents most antibodies and toxins, even cells, from going into the brain. During an injury, just for very short time the diaphragm is also damaged and allows passage. Unless the patient comes in this time, stem cells can't be delivered through the blood route.

Despite the country still lacking a law on stem cell therapy, the DCGI has allowed Stempeutics to conduct trials at multiple sites. The draft guidelines have been awaiting discussion almost since two years now. It is expected to be tabled in Parliament this summer.

There are plans to add a few more diseases to the present list under study. These include vitiligo (a skin eruption), dilated cardiomyopathy, end-stage liver disease, etc.

"By end 2009, we hope to have the first defined stem cell based drug for standard therapy on the shelf, just like all other medicines. This will be for a few of the diseases studied," says Manohar.

In the area of transplants too, stem cells can do miracles as witnessed when a heart taken from a cadaver came alive when a "stem cell scaffold" was introduced. Essentially, a 3-dimensional makes it easy for stem cells to multiply and form a whole new organ.

"This needs some amount of tissue engineering and we are working with some US universities as also Sri Thirunal Institute in Trivandrum who are experts in polymer science. Using biomimetic material which is also bio-degradable, we introduce a small heart inside the dead one. Eventually the scaffolding falls off and the stem cells have done their job," explains Dr Totey. This will be a big boon for transplants because stem cells can only help repair a damaged tissue if the damage is small but if the whole organ has failed, we need transplants, he adds.

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

 

Both have promise to improve patients' lives by implanting them into the patient's body to replace damaged or dead tissue. Both are ALREADY helping medical knowledge, such as drug development and understanding diseases in new ways.

ADULT stem cells (ASC) come from more sources than anyone can count. First was in the bone marrow, then the blood, then certain fat cells, then nasal skin, then the dam broke and we seem to find a new source in the body every month. ALL of these produce AUTOLOGOUS ASC, meaning from the patient's own body.

ASC include also non-autologous cells. The strongest seem to be from the placenta and the umbilical cords of healthy newborn babies, which can be frozen and used to help the baby decades later or a family member months later, or a stranger also.

ASC are already helping improve and extend the lives of patients with dozens of "incurable" diseases," 73 when you count only published scientific papers, well over 100 if you read all the reports from outside the USA you canfind.

Embryonic stem cells (ESC) are thought to be more powerful than ASC and maybe they are. They come from very early in a pregnancy and are the by-products of abortions and fertility clinics. However, ten years of research followed by animal tests seem to produce two results:
1--Disease symptoms can be reduced by ESC.
2--Animals die from tumors in too many cases.
Ergo--no approved clinical trials after ten years.

For more, go to any stem cell site that is NOT from an American institution.

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Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

Google News Alert for: adult stem cell - Feb 5, 2008


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To show you how far ahead of the USA all of Asia is, here is a typical piece from India. The first part of the article describes a fine use of embryonic stem cells (ANYTHING other than implanting these poisons into a human body is fine by me). The second half shows them starting to use adult stem cells successfully and unsuccessfully for certain diseases which will not ever be LOOKED AT by money-hungry American medical science. Take note, Michael J. Fox, since embryonic fakers must pretend that adult stem cells are worthless, by backing that which will kill you, you are effectivley destroying your ONLY chance at improvement. - Don Margolis

STEM the damage
Deccan Herald - Bangalore,India
Unlike usual bone marrow transplants where a litre of the liquid is drawn each time, with mesenchymal adult stem cells, all that is required is 30-60 ml ...
See all stories on this topic

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This article shows that there are more ways to find and more ways to use adult stem cells than science can keep up with. Next time you see an article in an American newspaper talking about embryonics, remember this when they say adult stem cells can't do as much as their cancer-causing embryonic stem cells. - Don Margolis

Gilbert doctor leads way for cardiovascular research group
East Valley Tribune - Mesa,AZ,USA
Dib recently earned approval for the second leg of his ongoing research that looks at using adult stem cells from thigh muscles to regenerate dead heart ...
See all stories on this topic

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posted new standard post 845pm eastern - Don Margolis

The State of Human Life
Town Hall - Washington,DC,USA
The development of adult stem cells is a great technical boon that may allow the culture to move beyond the ethical questions of the stem cell debate, ...
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