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Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
By PAT BRENNAN / ORANGE COUNTY REGISTER

Survival for brain-cancer patients treated with chemotherapy comes with a dark side: "chemobrain," the debilitating loss of memory and mental function that often follows.

Now scientists at the UCI Medical Center are preparing a new weapon that could one day clear the cognitive fog.By manipulating stem cells, researchers Daniela Bota and Mark Linskey, both doctors who also treat cancer patients, say they may be able to place a bull's eye over tumor cells and wipe them out, while leaving the brain intact.

Their successes so far have all taken place in a petri dish, and it will likely be years before they can try their method on human patients.

But already, one expert is calling their discovery "the first truly novel approach to brain tumor therapy in more than four decades."

"Our cause and our passion is to take care of patients," Bota told a recent visitor to her lab on the hospital's campus in Orange. "That always comes first."

The first step would be to modify chemotherapy drugs so they can kill cancer without killing the brain cells around it.

But the two scientists, who are part of the hospital's Comprehensive Brain and Spinal Cord Tumor Program, have far bigger ideas.

"We hope to be able to do transplantation with human neural stem cells, and try to re-create memory and cognition," Linskey said. "That is sort of our big dream."

Their potential treatment hinges on the bizarre similarities between tumors and healthy tissues in the human body.

Both, for example, have their own versions of stem cells, the precursors that give rise to a variety of organs and other structures.

In normal tissues, these cells receive chemical signals that prompt them to become one thing or another.

The vast potential of stem cells, in fact, is driving an explosion of discoveries, Bota's and Linskey's among them.

The world's first trial of a treatment for acute spinal cord injuries using human embryonic stem cells, developed by UC Irvine stem-cell researchers Hans Keirstead and Gabriel Nistor, is now underway.

Many other conditions, from Alzheimer's to fatal childhood diseases, could one day be treated using stem cells.

But the "stem cells" in tumors are of a decidedly destructive variety.

Instead of differentiating into brains or bones or kidneys, they proliferate wildly, their chaotic growth becoming the tumors that disrupt the body and brain, and eventually kill.

Stem cells are also the tumor's greatest weakness.

By aiming chemical weapons at features found only on the tumor stem cells – a protein, for example, on the surface of the cell – Bota and Linskey hope to turn the tables on tumors, disrupting their mad growth while having little or no effect on normal cells.

Their early work on the problem is already making waves in the scientific community, with other researchers seeking out the two scientists and their co-authors by phone or email, and comments and references showing up in scientific journals.

In March, they published their highly suggestive findings. They found that two commonly used chemotherapy drugs did profound damage to neural stem cells, provided by Dr. Philip Schwartz at the Children's Hospital of Orange County and grown in their laboratory.

But the drugs had little effect on the tumor stem cells, or "glioma stem-like cells."

Meanwhile, two newer chemotherapy drugs had the opposite effect, causing little damage to the neural cells but knocking down tumor stem cells.

It's a long way from the petri dish to trials in human patients; tests on laboratory rats will come first.

And the findings by themselves also don't prove the connection between the resistance of tumors to some forms of chemotherapy and the "chemobrain" that later plagues patients.

But if the theory stands up to scientific scrutiny, it could make a huge difference in the lives of cancer survivors -- not only brain-cancer patients, but those who beat other forms of cancer and also suffer chemobrain.

Among them are breast-cancer patients, who show a 70 percent rate of memory loss after chemotherapy.

Children could be among the biggest beneficiaries of a chemobrain treatment, Bota said. They can have as high as an 80 percent survival rate after chemotherapy for brain cancer.

But the cognitive deficits that result can lower their quality of life and make it difficult, and perhaps impossible, to get on with their young lives: go to school, get a job.

"What you see at the end is the tumor in remission, the patient in dementia," Bota said.

For adults, such effects might explain why divorce rates among brain cancer patients are high.

"What we hear over and over again is, 'This is not the person that they used to be,'" she said.

It gets down to what Linskey believes could become a fundamental shift in the standards doctors use to decide whether or not a treatment is successful.

"The brain defines who we are as a person," he said. "The goal is to have the same person at the end of the treatment as you had when you started."

Article Tab: Cancer doctors Mark Linskey and Daniela Bota look over plans for experiments at the UC Irvine Medical Center. They hope to do battle with chemobrain, a loss of memory and mental function that can follow chemotherapy treatment.
Cancer doctors Mark Linskey and Daniela Bota look over plans for experiments at the UC Irvine Medical Center. They hope to do battle with "chemobrain," a loss of memory and mental function that can follow chemotherapy treatment.

Posted: 8/4/2011 3:25:15 PM by Don Margolis | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.

Stem Cell Research for COPD


Thanks to stem cell research, a Florida female smoker, Barbara Mckean who was on oxygen 24 hours per day before stem cell therapy using her own Adult Stem Cells is now OFF oxygen totally after the treatment in the Dominican Republic.

Barbara Mckean is now enjoying life after the stem cell research done by cardiologist Dr. Zannos Grekos of the Repair Stem Cell Institute helped Barbara's COPD repair the damage done in the lungs by years of smoking.

Stem Cell Video for Lung Disease and COPD


In this video, both Barbara and Dr. Zannos Grekos are interviewed about how the stem cell research and treatment helped her COPD and repair the lung disease:
Special Note: If you have trouble viewing this stem cell video, please go to this stem cell link



Stem Cell Research Video Transcript


Below, you will find the transcript of the stem cell video above for lung disease.

Host: "Regenocyte Therapeutic is a world leader in stem cell therapy. They are dramatically improving the lives of people who have been diagnosed with life altering cardiac and vascular diseases. And joining us to talk about Regenocyte Therapeutic is Dr. Zannos Grekos. He is the Director of Cardiology and Vascular Diseases and Barbara Mckean praise god - she is a stem cell therapy patient. She was treated in December 2008 for severe lung disease. She is doing fantastic. I'm so glad to have both of you here today.

Dr. Grekos: We're thrilled to be here

Host: You were here last year.

Dr. Zannos Grekos: About a year ago.

Host: And I know a lot has gone on since then. But for people just tuning in.they hear stem cell therapy they hear stem cells and politically speaking it is a hot topic, but I want to talk about the differences between what you are doing with your company Adult Stem Cells and then there are Embryonic Stem Cells. Can you give me kind of a Cliff Notes version on what's up with both of those.

Dr. Grekos: There is a big difference and that is one of the things that Regenocyte is focused on- is educating the public. Embryonic stem cells come from in-vitro fertilization clinics and that is where all the controversy is surrounding and but also these stem cells are from somebody else so there are issues with rejection and also a high risk of cancer. So the FDA and the medical community are very concerned with the use of Embryonic Stem Cells.

Host :So they really aren't embracing that?

Dr. Grekos: Exactly, not embracing it, very hesitantly looking at it. we have not done any human trials yet so we have never actually treated anybody with embryonic stem cells.

Host: Now, what is stem cell therapy exactly, cuz you are using Adult Stem Cells..

Dr. Grekos: we are using Adult Stem Cells, these cells come from the patients themselves, so they are your own cells. ANd these cells are tiny little cells that float around and they are designed to repair wear and tear and damage in our own bodies and what we do is take them out from the body with just a simple blood draw as if you are donating blood and extract out the stem cells and activate them and multiply them so we supercharge them and then we put them back into whatever organ is damaged or diseased such as heart attack or lungs in Barbara's case.

Host: Now let's talk about Barbara. Barbara tell me about your condition and what you were diagnosed with.

Barbara Mckean: I had COPD , and it was end stage. and I was on Oxygen 24/7.

Host: And you are a young woman too and to be on oxygen constantly, you are happily married, but you can't get around cuz you can't do a whole lot.

Barbara Mckean: It is very difficult

Host:And you were a smoker.

Barbara: Yes, I was a smoker.

Host: And i know a lot of you out there are saying ok I have COPD, I have some of these issues
Now tell me what happened. Your husband stumbled upon an article.

Barbara: Yes, my husband read an article about Dr. Zannos Grekos and a seminar he had. So we went to the seminar and the rest is history.

Host: So you had the procedure done and the procedure was done in November, so how long was it before you had positive effects.

Barbara: I noticed positive effects right away, I really did. I had a feeling of well being the very next day. And then 2 days before Christmas on December 23rd it was a defining moment, I woke up and told my husband and said "I don't need the oxygen!"

Host: WOW! So you were on it 24/7 and now you are not on it?

Barbara: Yes, I am not on it at all. It was reduced to 2 Liters and then completely off.

Host: I want to talk to Dr. Grekos, there are so many amazing stories like this. So what are some of the other health conditions that they are using the stem cells in?

Dr. Grekos: Some of the major conditions that we are having a lot of success with is heart disease- patients who have suffered heart damage from heart attacks, or even viruses where their hearts are enlarged we were able to regenerate the damaged heart tissue and improve the heart function. We are also able to treat senile dementia where the brain is starting to wear and tear and the stem cells will actually regenerate the blood circulation to the brain and the brains cells as well

Host: And remember everybody, these are your own stem cells.

Dr. Grekos: Yes, your own stem cells. And this is work that is being done internationally we are also doing a lot of clinical studies here in the US. But as far as availability goes, it is nice to make this available.

Special Note on Stem Cell Treatment


If you or someone you love has COPD or perhaps another disease, If you are interested,

Go to The Repair Stem Cell Institute website

Right side of page, click on STEM CELL TREATMENT NOW.

Fill out the form and click SUBMIT. You will get an immediate answer listing some more facts about stem cell treatments.

Within a few days you will get a personal answer for the medical condition you inquired about.

This service is free.
Posted: 5/4/2009 12:36:31 PM by Don Margolis | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
Lots of news recently about storing stem cells taken from a baby's cord blood.  There now seem to be three options when a woman has a baby:

  1. All of these new companies offering to store your baby's cord blood, offering the "security" of using perfectly matched stem cells should there be something wrong with your baby. This may cost the parents to the tune of around $2,000-$3,000.  However, the parents of these Cerebral Palsy sufferers-  Dallas Hextell, Chloe Levine, Maia Friedlander, and John Centrello are quite happy they stored their child's stem cells

  2. Another option when a baby is born is for the parents to donate their baby's cord blood stem cells to a public bank- where the stem cells may match with an unknown child stricken with Leukemia perhaps.  This costs the parents nothing and has the reward of knowing you may be saving someone's life.

  3. The last option shouldn't even really be an option- throwing the cord blood away.  Yes, it is the parents' rights to do whatever they wish to do with it, but it is a waste to simply throw something away that has no ethical issues and could possibly save someone's life.


Obviously, I recommend 1 or 2, but it is up to the  parents obviously.  This article explores the issue in more depth concluding that donating is the better choice:

"The rates of actual use of the stored cord blood in private banks is minuscule; I discourage storage in private banks," he said.

Donation to public cord blood banks, however, is extremely useful. Donation is free. These banks maintain high quality samples and can be accessed by any patient who needs it. While the likelihood of any person using their own cord blood may be low, the likelihood of someone's cord blood being used in the general public is markedly higher.

Also, here is a very lopsided article in Newsweek called "When Medicine Meets Marketing- The business of storing umbilical-cord blood is growing. Is salesmanship outpacing science?"

Yes, just by that subtitle, you can see how "neutral" the story is going to be.


The article basically implies that not only are these private storage companies expensive for cord blood stem cells- they are saying that even on the small chance that a child may need his own stem cells for something like Cerebral Palsy-  that it is "unproven" to work.    Ridiculous.  The article concentrates on Dallas Hextell (one of the kids I mentioned above) and then asks  how the other kids treated with their own cord blood stem cells are doing.   If the Newsweek reporter had done a little more research, she would have dug up  the 4 kids I did who were part of the same study as Dallas Hextell.   In other words- this 74 year old old man did more research than a Newsweek reporter.  It is no wonder that people are now tuning out the mainstream media.

One of the commenters to the articles said it best-

Posted By: aussie142 @ 12/17/2008 8:50:19 PM


It seems like you have a problem with the future of medical research on this subject,and by reading this article,you seem very negatively one sided against this registry.I dont know anybody personally with CP (cerebral palsy) ,but being a paramedic,responding to incidents to help these patients,and seeing the devasting effects of this on the patients as well as the care givers,I would think anything that can be done to "heal" or just slow down the progression of this Illness,should be done.Wether its public or private,stem cell research is just touching the surface,and I beleive that medicine will find out more benefits ,probably using a pts own stem cells,that we have no idea about right now.I know we dont know a real lot on this subject,but come on,wouldnt you want everything done that could be done?What if we didnt have a system in place to bank your childs own stem cells,to find out in 10 or 20 yrs from now,we can cure cancer,dementia,or who knows what else utilizing your OWN stem cells from cord blood?Shame on your 1 sided negative reporting skills here,Im glad Im not a journalist....!!!!





Posted: 12/18/2008 3:43:44 PM by Don Margolis | with 0 comments


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