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Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.

EU's top court opens door to some stem cell patents

By Robert-Jan Bartunek and Ben Hirschler - BRUSSELS/LONDON Thu Dec 18, 2014 8:23am EST

A piece of a three-dimensional bone structure obtained from the own adipose stem cells of a patient is seen at Brussels' Saint Luc Hospital January 14, 2014.  REUTERS/Yves Herman

A piece of a three-dimensional bone structure obtained from the own adipose stem cells of a patient is seen at Brussels' Saint Luc Hospital January 14, 2014.

Credit: Reuters/Yves Herman

(Reuters) - Europe's top court has opened the door to certain stem cell patents in the European Union by ruling that an organism incapable of developing into a human being is not a human embryo and may be patented.

Thursday's judgment by the European Court of Justice was made following a case brought in Britain by U.S. company International Stem Cell Corporation (ISCO.PK) over whether it could patent processes covering the use of human egg cells.

The case is significant because three years ago the EU court ruled that stem cell research involving human embryos could not be patented, a decision condemned at the time by some scientists as a "devastating" blow for medical research in Europe.

As a result of that 2011 ruling, Britain's patent office objected to a patent application from the California-based company.

Although work on stem cell therapies is still experimental, researchers believe they have potential to treat a range of diseases from Parkinson's to blindness. But rigid curbs on obtaining patents could hobble their commercialization.

International Stem Cell, however, uses processes based on unfertilized human eggs and the EU court ruled that such eggs should be excluded from the ban on embryo-derived stem cell patents, if it was proven they could not develop into human beings.

"The mere fact that a parthenogenetically-activated human ovum commences a process of development is not sufficient for it to be regarded as a 'human embryo'," the court ruled. Parthenogenesis is the development of unfertilized eggs.

The court said it left it to British judges to determine whether the specific cells used by the U.S. company lacked the inherent capacity of developing into human beings and therefore met these criteria.

Adam Cooke, a partner at law firm DLA Piper, representing International Stem Cell, said the court's decision was "a big step in the right direction". In addition to the patent application in Britain, the company is also seeking patents at the European Patent Office.

Its parthenogenetic stem cells are in pre-clinical development for treating severe diseases of the eye, the nervous system and the liver.

Stem cell research has long been controversial. Critics argue that using embryonic stem cells is wrong because obtaining these cells involves the destruction of embryos which are left over from fertility treatment.

Scientists contend the research is justified, since the embryonic stem cells they use are cell lines derived from original surplus eggs that can be maintained indefinitely. While adult stem cells are also being investigated as potential medicines, they are less flexible than embryonic ones.

Posted: 12/19/2014 12:28:51 PM by Don Margolis | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
"WHERESOEVER YOU GO, GO WITH ALL YOUR HEART." - Confucius
 
FACT:  Female stem cells are better at regeneration than male stem cells. 
 
QUESTION:  Is this why women have fewer heart attacks? 
ANSWER:  Actually, women don't have fewer heart attacks than men. 
 
Heart disease is the leading cause of death for women in the United States, killing 292,188 women in 2009—that’s 1 in every 4 female deaths.1

Although heart disease is sometimes thought of as a "man's disease," around the same number of women and men die each year of heart disease in the United States. Despite increases in awareness over the past decade, only 54% of women recognize that heart disease is their number 1 killer.2
 
The fact is, women have heart attacks at about the same rate as men...but their stem cells ARE still better.  Male or female, if you have cardiac disease, there is hope! 
 
Heart stem cell treatment info: http://heartstemcells.com/
 
- Repair Stem Cell Institute
 
heart.jpg
Texas Heart Institute

Female stem cells could be better for heart repair, disease treatment - Nov 16, 2014
 
Above is a pig heart, which has been stripped of all its cells, leaving only the scaffolding to grow a new heart with human stem cells. This approach may be used in the future to repair heart damage or even generate new hearts for transplantation. Pig hearts are used because they are of a similar size and complexity to human hearts.

 “We always knew women were awesome,” said Doris Taylor, director of  Regenerative Medicine Research at the Texas Heart Institute. “Now we have the science to back it up.”

...female stem cells, derived from animal muscle tissue, generated more muscle fiber and survived better when repairing injured muscle than male cells... via

Additional research from ScienceDaily - 2007
Posted: 12/17/2014 11:11:59 PM by Patrick Dalton | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
baby_bath_s2.jpg 
"BUBBLE BABY" CURE!
Groundbreaking!  First ever! Pioneers!  New breakthrough!
There's only one problem...
 
THE OFFENSE:
It gets harder and harder to celebrate the medical advances when the media and medical industry promote those advances as "the world's first" and...they are completely lying with abundant documented proof to the contrary.
 
THIS WEEKS (BS) HEADLINES:
  • Doctor discovers cure for 'Bubble Baby' disease
  • Stem Cell Researcher Pioneers Gene Therapy Cure for ...
  • and from our friends a CIRM:
"Today, a UCLA research team...announced a stunning breakthrough cure..."
 
THE PROBLEM:
So what's the problem?  Nothing much, just that they are 12 years late! 

In 2002, Israeli and Italian Scientists treated and cured two babies with "Bubble Baby" disease, the rare and fatal hereditary condition known as Severe Combined Immunodeficiency, or SCID.  The two babies, a two-year-old baby girl named Salsabil from East Jerusalem and an Italian girl, received a correctly functioning gene in place of the faulty gene that causes the disease...both babies have returned to their homes and are leading normal lives. via
 
THE PROOF:
Notice these headlines and their associated dates.
 
MORE PROOF - THE PATENT: (Yes, they even patented the procedure!)
  • Israeli Researcher Patents Cure for 'Bubble Boy' Disease - 3/8/2009, 9:37 PM
 
We at RSCI are particularly bothered by this story because the accomplishments of a great man and brilliant doctor and scientist are going unsung so the "California Institute of Revisionist Medicine" can spout their misinformation and claim an huge and unearned victory.
 
THE PUNCH LINE: 
The doctor who cured the first 'bubble baby' in the world has been not only a friend, but also a member of our scientific board and a premier treatment destination of RSCI since the inception of our organization. 
 
-Repair Stem Cell Institute
 
---------------------------------

UCLA Stem-Cell Researcher Cures Children With ‘Bubble Baby’ Disease
Posted 2:59 PM, November 18, 2014  -  "A UCLA medical researcher was lauded Tuesday for developing a groundbreaking new stem-cell gene-therapy treatment..." via
(Sorry California, not even close! - RSCI)
Posted: 12/11/2014 11:21:42 PM by Don Margolis | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
GUWAHATI: A 61-year-old heart patient from Silchar successfully underwent a stem cell operation at a private hospital here after stem cells extracted from his bone marrow were used to regenerate worn-out cells in his heart. Hospital authorities said the procedure was performed in the northeast for the first time.




http://www.vectorfree.com/media/vectors/cardiac-vector.jpg

The patient, Gopal Krishna Goswami, underwent the procedure on November 21. Diabetic Goswami's heart was functioning at 29% of its capacity due to degeneration of cells. In medical parlance, he was suffering from 'chronic poorly compensated heart failure'.

 

"Stem cell therapy provides hope in cases which are beyond the reach of conventional treatment. Goswami was suffering from a weak heart. His heart had almost stopped pumping blood and he couldn't even walk a few steps," Goswami's surgeon Bikash Rai Das said.

The bone marrow was extracted from his hip bone, said the doctor. It was then sent to a facility in Mumbai for extraction of stem cells. The procedure was carried out in collaboration with the Mumbai-based stem cell bank and therapy centre. With stem cell therapy becoming increasingly popular, its introduction in the region is expected to usher in positive changes in the northeast's health sector.

Goswami will have to go through five sittings of stem cell infusion and his next sitting will be within 45 days, his doctor said. A therapy of this sort requires screening by a government-approved ethics committee. The candidate's medical history is probed before the go-ahead is given. Screening can take anything between seven to 10 days.

Stem cell therapy provides hope in cases which are beyond the reach of conventional treatment.
Posted: 12/4/2014 10:27:42 AM by Don Margolis | with 0 comments


Are you or a loved one interested in receiving stem cell treatment? For free information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box and the MEDICAL CONDITION in the message.
NIH scientists find that restocking new cells in the brain’s center for smell maintains crucial circuitry.

For decades, scientists thought that neurons in the brain were born only during the early development period and could not be replenished.  More recently, however, they discovered cells with the ability to divide and turn into new neurons in specific brain regions. The function of these neuroprogenitor cells remains an intense area of research. Scientists at the National Institutes of Health (NIH) report that newly formed brain cells in the mouse olfactory system — the area that processes smells — play a critical role in maintaining proper connections. The results were published in the October 8 issue of the Journal of Neuroscience. 
 
“This is a surprising new role for brain stem cells and changes the way we view them,” said Leonardo Belluscio, Ph.D., a scientist at NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and lead author of the study.
 
The olfactory bulb is located in the front of the brain and receives information directly from the nose about odors in the environment. Neurons in the olfactory bulb sort that information and relay the signals to the rest of the brain, at which point we become aware of the smells we are experiencing. Olfactory loss is often an early symptom in a variety of neurological disorders, including Alzheimer’s and Parkinson’s diseases.

In a process known as neurogenesis, adult-born neuroprogenitor cells are generated in the subventricular zone deep in the brain and migrate to the olfactory bulb where they assume their final positions. Once in place, they form connections with existing cells and are incorporated into the circuitry.
 
Dr. Belluscio, who studies the olfactory system, teamed up with Heather Cameron, Ph.D., a neurogenesis researcher at the NIH’s National Institute of Mental Health, to better understand how the continuous addition of new neurons influences the circuit organization of the olfactory bulb. Using two types of specially engineered mice, they were able to specifically target and eliminate the stem cells that give rise to these new neurons in adults, while leaving other olfactory bulb cells intact. This level of specificity had not been achieved previously.    
 
In the first set of mouse experiments, Dr. Belluscio’s team first disrupted the organization of olfactory bulb circuits by temporarily plugging a nostril in the animals, to block olfactory sensory information from entering the brain. His lab previously showed that this form of sensory deprivation causes certain projections within the olfactory bulb to dramatically spread out and lose the precise pattern of connections that show under normal conditions. These studies also showed that this widespread disrupted circuitry could re-organize itself and restore its original precision once the sensory deprivation was reversed.
 
However, in the current study, Dr. Belluscio’s lab reveals that once the nose is unblocked, if new neurons are prevented from forming and entering the olfactory bulb, the circuits remain in disarray. “We found that without the introduction of the new neurons, the system could not recover from its disrupted state,” said Dr. Belluscio.
 
To further explore this idea, his team also eliminated the formation of adult-born neurons in mice that did not experience sensory deprivation. They found that the olfactory bulb organization began to break down, resembling the pattern seen in animals blocked from receiving sensory information from the nose. And they observed a relationship between the extent of stem cell loss and amount of circuitry disruption, indicating that a greater loss of stem cells led to a larger degree of disorganization in the olfactory bulb.
 
According to Dr. Belluscio, it is generally assumed that the circuits of the adult brain are quite stable and that introducing new neurons alters the existing circuitry, causing it to re-organize. “However, in this case, the circuitry appears to be inherently unstable requiring a constant supply of new neurons not only to recover its organization following disruption but also to maintain or stabilize its mature structure. It’s actually quite amazing that despite the continuous replacement of cells within this olfactory bulb circuit, under normal circumstances its organization does not change,” he said.
 
Dr. Belluscio and his colleagues speculate that new neurons in the olfactory bulb may be important to maintain or accommodate the activity-dependent changes in the system, which could help animals adapt to a constantly varying environment.
 
“It’s very exciting to find that new neurons affect the precise connections between neurons in the olfactory bulb. Because new neurons throughout the brain share many features, it seems likely that neurogenesis in other regions, such as the hippocampus, which is involved in memory, also produce similar changes in connectivity,” said Dr. Cameron.
 
The underlying basis of the connection between neurological disease and changes in the olfactory system is also unknown but may come from a better understanding of how the sense of smell works. “This is an exciting area of science,” said Dr. Belluscio, “I believe the olfactory system is very sensitive to changes in neural activity and given its connection to other brain regions, it could lend insight into the relationship between olfactory loss and many brain disorders.”
 
This work was supported by the NIH Intramural Program.
 
For more information about brain research, please visit http://www.ninds.nih.gov
 
NINDS is the nation’s leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. 
 
About the National Institute of Mental Health (NIMH): The mission of the NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery and cure. For more information, visit http://www.nimh.nih.gov.
 
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

ninds-10_l.jpg

Making “scents” of new cells in the brain’s odor-processing area
Adult-born cells travel through the thin rostral migratory stream before settling into the olfactory bulb, the large structure in the upper right of the image. Courtesy of the Belluscio Lab, NINDS.

Posted: 10/18/2014 4:20:10 PM by Don Margolis | with 0 comments


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