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META
Proper Research by Embryonic Scientists
Posted 28 February, 2008 in DON MARGOLIS | No comments
THE DREAM OF IMPLANTING EMBRYONIC STEM CELLS INTO HUMANS WILL NOT COME TO PASS, THOUGH THE BILLIONS “RESEARCHERS” ARE RIPPING OFF FROM TAXPAYERS WILL GO ON FOR YEARS. HOWEVER, THERE IS ONE LEGITIMATE USE FOR EMBRYONIC RESEARCH, AND THAT IS IN USING EMBRYONIC STEM CELLS TO TEACH US ABOUT DISEASES AND OTHER VITAL INFORMATION ABOUT HOW THE BODY WORKS.–DM
EXTRACTED FROM THE
http://www.deccanherald.com/Content/Feb52008/snt2008020550496.asp
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Stem cell therapy, though in a nascent stage, has been a promising area. Here in |
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Predicting human birth defects in a developing foetus by studying embryonic stem cells on a Petri dish, as also testing drugs in a more quicker and cost-effective way, is now possible, thanks to work done by a group of scientists. Researchers at the Manipal Institute of Regenerative Medicine and Stempeutics have come up with a way of designing safer drugs and understanding their effects on pregnancy and the development of the foetus. The early embryo growing in the mother’s womb can cross-talk with the maternal environment, and responds to the factors around it. Common bacterial infections of the maternal genital tract, like bacterial vaginosis, can lead to poor pregnancy outcomes. The EBs closely mimic a growing embryo in a mother’s womb. As ethical issues limit studies on the molecular in human embryos, the EBs are handy. The team led by Dr Kaushik Deb (Group leader and Principal Scientist, Embryonic Stem Cell Program) has shown that the presence of very low amounts of bacterial lipopolysaccahrides (LPS), a toxin found in E-coli in the environment, can cause defects in the development of tissues like the bones in the growing foetus. By testing drugs and toxins on these cells, drug discovery can skip valuable time spent on animal studies as well as cost. “The time for drug discovery can be cut from 14 to seven years on an average,” says Dr Satish Totey, Chief Scientific Officer, Stempeutics Research. It would also be a good tool for IVF clinics, he adds. The findings were recently published in the online version of the journal Regenerative Medicine. MIRM is a constituent institute of |
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ASIA SOARS AHEAD
Posted 28 February, 2008 in THE LATEST ASC SCIENCE | No comments
AS REGULAR READERS KNOW, I CONSIDER
HERE IS A FEB.2008 ARTICLE FROM
EXTRACTED FROM THE
http://www.deccanherald.com/Content/Feb52008/snt2008020550496.asp
Stempeutics has been doing some pioneering work on stem cells with a focus on “benchside to bedside”, as the manager, Manohar says. “We do not want to be doing research that is too basic to be applied.”
At present, four major clinical trials with 100 patients each are ongoing in cerebral strokes (!), limb Ischemia (!), myocardial infarction and multiple sclerosis (!). (OF THESE FOUR, ONLY MYOCARDIAL INFARCTION IS CURRENTLTLY IN CLINICAL TRIAL IN THE
Calling it experimental therapy, Manohar says that almost 80 patients have been treated using mesenchymal stem cells, found in the bone marrow. “In the last six months alone almost 40 patients have been treated and in 25 per cent of the cases, the results were good. While the Parkinson’s patients showed remarkable recovery (TAKE NOTE, MICHAEL J. FOX. AS CHRISTOPHER REEVE DID, YOU ARE WASTING YOUR LIFE CHAMPIONING EMBRYONIC SCIENCE FICTION WHICH EXISTS ONLY BY PRETENDING THAT WHAT CAN HELP YOU NOW—ASC– DOES NOT WORK—DM) with many even stopping the drug, with spinal cord injuries there was mixed results,” says Dr Totey. It was found that the cells were not migrating to the site.
One of the reasons he cited could be the mode of delivery of stem cells. Usually it is delivered at the site of injury, or through lumbar puncture or the arterial route. The site of injury is the best approach, though in the case of brain diseases, this means complications.
The stem cell treatment works well for fresh injuries but some experts believe that the body sends stem cells naturally in this period. After six months or so, the scar tissue forms and can hinder the migration of stem cells administered.
A patient from
Now she has recovered to a large extent, can move around and has control of the bladder, etc. She required two injections so far, of stem cells drawn from her bone marrow.
Unlike usual bone marrow transplants where a litre of the liquid is drawn each time, with mesenchymal adult stem cells, all that is required is 30-60 ml which can be cultured in the lab for future use as well, he says.
Unlike most other adult stem cells, mesenchymal are pluripotent and can grow into any tissue. The other big advantage is that there is no need for matching. Any donor can donate cells from his bone marrow. As it takes 20-25 days to culture the stem cells in lab, this is an advantage as readily available cells can be administered in emergency situations instead of having to draw from the patient’s bone marrow and culture.
“The problem is in isolation and culturing. Very small quantities of the cell are present in the bone marrow. We have patented the technology,” says Totey.
In the case of cerebral stroke, the problem arises in delivering stem cells due to the blood brain barrier. This is a natural barrier of the body which prevents most antibodies and toxins, even cells, from going into the brain. During an injury, just for very short time the diaphragm is also damaged and allows passage. Unless the patient comes in this time, stem cells can’t be delivered through the blood route.
Despite the country still lacking a law on stem cell therapy, the DCGI has allowed Stempeutics to conduct trials at multiple sites. The draft guidelines have been awaiting discussion almost since two years now. It is expected to be tabled in Parliament this summer.
There are plans to add a few more diseases to the present list under study. These include vitiligo (a skin eruption), dilated cardiomyopathy, end-stage liver disease, etc.
“By end 2009, we hope to have the first defined stem cell based drug for standard therapy on the shelf, just like all other medicines. This will be for a few of the diseases studied,” says Manohar.
In the area of transplants too, stem cells can do miracles as witnessed when a heart taken from a cadaver came alive when a “stem cell scaffold” was introduced. Essentially, a 3-dimensional makes it easy for stem cells to multiply and form a whole new organ.
“This needs some amount of tissue engineering and we are working with some US universities as also Sri Thirunal Institute in
Natalie Quintana - Spinal Muscular Atrophy
Posted 24 February, 2008 in ADULT STEM CELL VICTORIES! | No comments
February 21, 2008
Janaina Ferreira da Silva Lima MD reports that Natalie Quintana of Miami, who suffers from Spinal Muscular Atrophy (FSMA), was treated with adult stem cell therapy in the Viña Clinic in Argentina 14 September 2007. Prior to the therapy, Natalie used two canes to support her weight with her shoulders. Recent electromyography studies indicate some muscles have regenerated. See her video under the blogroll to the right (same title).
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Autologous Stem Cells
Posted 24 February, 2008 in MEDICAL DISCLAIMER | No comments
DON MARGOLIS IS A STRONG SUPPORTER OF AUTOLOGOUS STEM CELLS (CELLS DERIVED FROM THE PATIENT’S OWN BODY). HE RECOGNIZES ADVANCES ARE BEING MADE USING UMBILICAL CORD BLOOD AND/OR PLACENTA-DERIVED CELLS, ESPECIALLY IN THE NEW STEM CELL SPECIALTY OF NEUROLOGY. QUITE NATURALLY, THESE NON-AUTOLOGOUS ADULT STEM CELLS CAN ONLY BE PARTIALLY MATCHED TO THE PATIENT, AND WHILE SHORT TERM SUCCESSES HAVE BEEN VALIDATED, HE SUGGESTS SOME CAUTION UNTIL THE LONG TERM BENEFITS ARE CLEARER. WE ARE TRYING TO GET PROOF OF ONE-YEAR VIABILITY TO PUBLISH HERE.
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OH NO THEY DIDN’T!
Posted 19 February, 2008 in MAD ABOUT STEM CELLS! | No comments
For the 10th time in four years, Geron has announced an upcoming clinical trial. Maybe THIS time will turn out to be true, but I’m not betting on it. ~MASC
Geron aims to be first in human trials with ESCs
by admin
In a first, Geron made headlines at the BIO CEO conference in New York with its announcement that it could begin its first human trials using embryonic stem cells to treat spinal cord injuries as…
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DON’T WASTE YOUR TIME!
Posted 19 February, 2008 in MAD ABOUT STEM CELLS! | No comments
DON’T WASTE YOUR TIME!
THE BELOW INVITATION TO A CONVENTION OF EMBRYONIC LIARS IS TYPICAL. NOTE HOW THE WORD “EMBRYONIC” IS NEVER MENTIONED IN THIS ARTICLE. THEY’D LOVE TO HAVE YOU ARRIVE IN A WHEELCHAIR SO THEY COULD SCREAM FOR BUSH’S HEAD AND PANDER TO PATIENTS BY TELLING THEM EMBRYONIC CURES ARE JUST WAITING FOR BUSH TO LEAVE OFFICE.
KNOW THAT VIRTUALLY ALL THE LISTED SPEAKERS ARE EMBRYONIC LIARS, DESPITE THE INTENTIONALLY-OMITTED WORD, AND REPRESENT ONLY THOSE WHO WOULD HAVE YOU BELIEVE THE “BIG LIE” OF AMERICAN MEDICAL SCIENCE: ADULT STEM CELLS DON’T WORK. IN THE CORRUPT WORLD OF CALIFORNIA POLITICAL CORRECTNESS, THAT SIX BILLION THEY ARE STEALING FROM THE TAXPAYERS CAN ONLY GO INTO THE MONEY-GRUBBING HANDS OF EMBRYONIC SCIENCE FICTION RESEARCHERS, WHOSE REAL MOTTO IS “WE WILL LIE AND YOU WILL DIE, BUT WE WILL PROFITEER.”
(IF YOU DO SHOW UP, ASK THEM WHERE THEY GET THEIR MONEY. THEN WATCH THEM SQUIRM.)
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NEUROBLASTOMA - STEM CELLS - UMBILICAL CORD - 2 YEARS OLD
Posted 19 February, 2008 in ADULT STEM CELL VICTORIES! | No comments
After receiving unusual stem cell transplant, Coppell toddler comes home from hospital
…Doctors released the 2-year-old from Medical City Dallas Hospital, where he spent nearly two months in treatment for neuroblastoma, which is a fast-growing cancer of the nervous system.
The centerpiece of Caden’s care was an unusual transplant, in which stem cells taken from his own umbilical cord at birth were pumped back into his body Dec. 28…
A NEW VICTORY: USING ASC TO TREAT CANCER IS VERY OLD NEWS, BUT USING ASC DERIVED FROM UMBILICAL CORDS IN THE USA IS A BIG STEP IN THE RIGHT DIRECTION. OF COURSE, THE USA, BEING THE BANGLADESH OF STEM CELLS, IS WAY BEHIND CHINA IN USING CORD BLOOD TO TREAT “INCURABLE” DISEASES. (NOTHING IN THE ARTICLE ABOUT FDA APPROVING THIS NEW THERAPY) MOST IMPORTANT, HOWEVER, IS THIS QUOTE.
- DM
Dr. Joel Weinthal, a Texas Oncology physician who is treating Caden, says it’s the boy’s best shot against a deadly disease that comes back about half the time. “We’re not talking about his being cured of his neuroblastoma right now,” said Dr. Weinthal. “It’s certainly a very positive thing that he gets to go home from the hospital, but he has a long road ahead of him.”
THAT QUOTE IS 100% SPOT-ON. SO I AM PRAYING FOR CADEN (AND OTHERS TO FOLLOW) TO STAY WELL, THOUGH I SUSPECT HE WILL NEED MORE CELLS IN THE FUTUR.
-DM
Stem Cell therapy treated patient with stroke and seizures
Posted 19 February, 2008 in ADULT STEM CELL VICTORIES!, DON MARGOLIS | No comments
Placental stem cell therapy for biological solutions to hitherto incurable diseases
Stem Cell therapy brought hope to millions, suffering from degenerative diseases and Wallena Haynes is one amongst number of beneficiaries. Wallena Haynes was always a fast paced individual with varied background in management positions and was working as manager of a senior retirement resort from last 4 years. But she had to leave her job as she began to having Seizures at the age of 35 and before resigning from the job she was also suffering from stroke. These degenerative disorders left her quite limited in her mobility and speech pattern. She was in the same stage from one and half year. She visited many facilities and was examined by numerous physicians where she spent thousands of dollars in the hope of finding a cure. But she was not, as none has been ever found.
After a year or so, a light of hope arisen when her husband’s doctor recommended her for placenta stem cell implant. Just in few days after the implant she was amazed with improvement in kidney function, energy level soared, her speech pattern returned to normal within 3 weeks and within 5 weeks she had full mobility of her limbs. Within 6 weeks she went back to work full time to her previous job and within small period of time promoted as Regional Manager, handling 6 retirement resorts. Now she is seizures and stoke free and able to reduce her medicine intake. She feels so blessed with improvements on daily basis and thankful for quality of life.
Wallena Haynes story itself tells every thing. But some people are initially still hesitant about using placentas in this fashion, but will be soon convinces of morality, safety and its benefits.
For more information about Wallena Haynes and placental Stem Cell therapy
Contact: Stem Cell Panakea
Web Site: www.stemcellkp.com
Email: info@stemcellkp.com
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MAL practice - just use adult stem cells already!
Posted 19 February, 2008 in MAD ABOUT STEM CELLS! | No comments
One of the Most Ridiculous Studies on Weight Loss Ever Published
A truly ludicrous study purports to show that a weight-loss surgery called adjustable gastric banding works better than conventional medical treatment for Type 2 diabetes in the obese.
Type 2 diabetes is usually brought on by obesity, and patients can often rid themselves of the disease entirely by losing about 10 percent of their body weight.
Adjustable gastric banding consists of looping a band around the top of the stomach to cinch it into a small pouch. 25 to 30 percent of the more than 200,000 weight-loss operations performed in the United States last year used gastric banding.
Of course, weight-loss surgeries can result in black-outs, malnutrition, infection, bowel and gallbladder problems, and an increased risk of death, but these facts are largely missing from reporting on the study.
The study’s lead author, Dr. John Dixon, says he believes that, “[D]iabetes surgery will become common within the next few years.” The reasons for his position might become a little clearer when you realize that Dr. Dixon has received research grants and speakers’ fees from Allergan Health, the company that makes the gastric bands. The company also paid for the study in question.
Sources:
* New York Times January 23, 2008
* Journal of the American Medical Association January 23, 2008; 299(3):316-23
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Do you know the difference between Adult and Embryonic stem cells?
Posted 16 February, 2008 in DON MARGOLIS | No comments
ADULT stem cells (ASC) come from more sources than anyone can count. First was in the bone marrow, then the blood, then certain fat cells, then nasal skin, then the dam broke and we seem to find a new source in the body every month. ALL of these produce AUTOLOGOUS ASC, meaning from the patient’s own body.
ASC include also non-autologous cells. The strongest seem to be from the placenta and the umbilical cords of healthy newborn babies, which can be frozen and used to help the baby decades later or a family member months later, or a stranger also.
ASC are already helping improve and extend the lives of patients with dozens of “incurable” diseases,” 73 when you count only published scientific papers, well over 100 if you read all the reports from outside the USA you canfind.
Embryonic stem cells (ESC) are thought to be more powerful than ASC and maybe they are. They come from very early in a pregnancy and are the by-products of abortions and fertility clinics. However, ten years of research followed by animal tests seem to produce two results:
1–Disease symptoms can be reduced by ESC.
2–Animals die from tumors in too many cases.
Ergo–no approved clinical trials after ten years.
For more, go to any stem cell site that is NOT from an American institution.
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