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New Stem Cell Research for Unhealed Bone Fractures

A medical team is reporting new stem cell research using Adult Stem Cells to heal broken bones in the foot and ankle. The Adult Stem Cell product called "Trinity" was used to heal bone fractures  in the foot and ankle of 21 people that failed to connect properly after the initial healing.

Clinical Results of Adult Stem Cells For Unhealed Foot and Ankle Fractures

Dr. Shannon Rush, of Palo Alto Medical Foundation presented his results of using Adult Stem Cells in the Journal of Foot and Ankle Surgery for March, 2009:

A review was conducted of 23 patients who underwent implantation of mesenchymal stem cell allograft for revision foot or ankle surgery. Composed of viable mesenchymal stem cells derived from cadaveric donor tissue, the graft had osteogenic, osteoinductive, and osteoconductive properties, and was capable of direct new bone formation at the site of implantation. In all of the cases, radiographic new bone formation was observed at the area of implantation and a 91.3% union rate was observed, and no evidence of graft rejection or complications associated with implantation were recorded.




Let me try to translate that-  the doctors took 23 patients who had broken bones or previous fractures  in their foot or ankle that did not heal properly (or nonunion is the clinical term).  As a result, they had difficulty and/or pain when walking.

21 out of the 23 patients who were implanted with this adult stem cell product "Trinity" achieved "bone union" and healing which allowed them to walk in regular shoes with little or no pain after their casts were removed.

What is Trinity?

Trinity is a mixture of donated adult stem cells combined with crushed bone from a bone bank.  It's full name is Trinity Multipotential Cellular Bone Matrix.


I previously covered Trinity and how it was used  for spinal fusions.  Most importantly, Trinity is already approved by the US FDA.

What This Means For Unhealed Bone Fractures

According to the Trinity website:

Trinity is an effective alternative to autograft in virtually all orthopedic applications. Essentially, for every surgical indication where autograft would be selected by a surgeon to be a bone void fill or bone growth stimulator, Trinity can be used. Trinity is not intended to be be used as an autograft "extender." It is intended to be a substitute for autograft.

An estimated 600,000 Americans suffer from unhealed bone fractures, so for any orthopedists or podiatrists or patients reading this- this is good news for you. Since it is FDA approved, I imagine if you wanted the "Trinity" adult stem cell product, it would be available for use-  "ask your doctor".

Some of the Repair Stem Cell Institute's doctors already use adult stem cells for bone fractures

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

It seems like everyday, they are finding a new way to use stem cell treatment.  Today, I have a story on repair (adult) stem cells being used for spinal fusion.  Chronic back pain affects millions of people around the world.  Sometimes, back surgery or "spinal fusion" is the only solution to their back pain.  Well, "spinal fusion" just got a lot easier thanks to stem cell therapy.  Quicker recovery time, less pain, and most likely a better outcome- what's not to like about repair stem cells?  Read on about this back patient, Leslie Mignona:

She decided on spinal fusion, which helps reduce nerve pain by stabilizing the spine.

But instead of the traditional approach, she opted for a new procedure using adult stem cells to fuse her spine together.

"I think it's extremely exciting," orthopedic surgeon Dr. Kam Momi said.

Momi said stem cells offer an alternative to traditional spine fusions, which are done using a patient's own bone.

"What we did was make a separate incision at the pelvis, scrape out bone from the inside of the pelvis, and pack that into the spine where we wanted it to go," Momi said.

With the new stem cell procedure, disc space is filled with a material called "Trinity." Trinity is a mixture of donated adult stem cells combined with crushed bone from a bone bank.

Once the material is in the spine, the cells go to work.

"They genetically turn on the switches to make bone cells, and eventually the bones fuse together," Momi said. (YES! Repair Stem Cells doing their job!- DM)

Recovery time is fast, lasting only about three months, compared to the year-long recovery associated with traditional fusions.

Click here to read the whole thing

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

REMEMBER WHEN YOU WERE BACK IN GRADE SCHOOL AND ONCE A YEAR- THE TEACHER WOULD CALL A TIME OUT AND AN UNFAMILIAR DOCTOR/NURSE WOULD DO A CURSORY CHECK OF EACH STUDENT'S BACK? WELL, I AND MOST OF MY FELLOW CLASSMATES DIDN'T KNOW THAT THEY WERE CHECKING FOR SCOLIOSIS- AN ABNORMAL CURVATURE OF THE SPINE:

"If the curve progresses, it can have profound affects on heart and lung function," said Mark A. Flood, D.O., an orthopaedic spine surgeon at Banner Desert Hospital in Mesa, Ariz.Surgery to correct scoliosis used to mean cutting a large piece of bone from the iliac crest in the pelvis, then using it to create a spinal fusion so the curve didn't get worse."The problem with taking bone from the iliac crest is it's a significant source of pain sometimes even permanent pain," Dr. Flood said. "It requires another incision, potential risk of infection, and that bone is gone forever."But Matthew was able to take advantage of a brand new therapy -- recently cleared by the FDA (ARE YOU KIDDING ME?-DM) -- to repair his spine using stem cells harvested from his own bone marrow (ADULT STEM CELLS!- DM) .Used with bone from the Bone Bank, Matthew's stem cells would act as a sort of catalyst to support the growth of new bone along the spine and work with permanent screws and rods to fuse it into the correct position. The surgery reduced Matthew's curvature from nearly 50 degrees to just 15 degrees.

Just three months after surgery, Matthew's already playing one-on-one with twin brother Jordan, getting stronger every day."I'm able to shoot, dribble, run and jump," Matthew told Ivanhoe. "If this is any indication of what's going to happen I think it will just get better."

CHALK ONE UP FOR YET ANOTHER CONDITION/DISEASE HELPED WITH ADULT STEM CELLS. I AM AMAZED (BUT THRILLED) THAT THIS WAS APPROVED BY THE FDA. PERHAPS THIS WILL SOMEHOW OPEN THE DOOR FOR OTHER ADULT STEM CELL TREATMENTS TO BE AVAILABLE HERE IN THE UNITED STATES IN THE VERY NEAR FUTURE.

CLICK HERE TO READ THE WHOLE ARTICLE

Are you or a loved one interested in receiving stem cell treatment? For free treatment information, please fill out our treatment form or email me don@repairstemcells.org and just put TREATMENT in the subject box.

 

CHANDLER TEEN HAS FIRST AZ STEM-CELL SPINAL OPERATION

 

Arizona Daily Star/ West

Chandler teen has first AZ stem-cell spinal operation

By Mary K. Reinhart - East Valley Tribune

Tucson, Arizona | Published: 12.15.2007

 

MESA ‚ Matthew Baremore woke up Tuesday morning, finished his book report on a Tom Clancy novel, and prepared to make medical history.  The 14-year-old Chandler boy, who has scoliosis, became the first in the state to undergo spinal fusion surgery using a concentrated cocktail of his own stem cells and donated bone.

 

The stem-cell technology speeds healing and helps Matthew's body to grow new bone along his curving spine. It also averts the need for a second procedure to harvest a piece of Matthew's bone‚¦

 

During the four-hour operation at Banner Desert Children's Hospital, Dr. Mark Flood, a pediatric spine surgeon, harvested bone marrow from the teen's pelvic bones. Stem cells were extracted from the marrow using centrifuge technology patented by a firm in Austin, Texas.

 

Flood straightened and bolstered Matthew's spine with a series of rods and pins ‚ a typical surgical treatment for severe scoliosis. Then the surgeon combined Matthew's own stem cells, which had been concentrated to pack about 10 times more cells than the traditional method, with crushed bone from the hospital bone bank.

 

He injected the puttylike mixture into the upper-middle section of Matthew's spine, between the rods, where the mixture will grow into bone and protect the spine against further curvature.

 

"What's revolutionary is the use of the concentrated stem cells," Flood said before the surgery. "We can avoid the pain of taking bone, and increase fusion."

 

To read the complete article:

http://www.azstarnet.com/allheadlines/216362